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How to apply AI to your B2B marketing strategy effectively

Mateo Rubio Dec 19, 2025
6 min

Implementing AI in your B2B marketing strategy is no longer optional—it’s a competitive advantage. Here’s how to use it effectively to generate more and better leads, automate key processes, and increase ROI.

Why AI has become essential in B2B marketing

B2B is complex: multiple decision-makers, long sales cycles, and highly technical products. In this context, AI helps you:

  • Analyze large volumes of customer and behavioral data
  • Personalize content and messaging by industry, role, or funnel stage
  • Optimize multichannel campaign management with greater precision
  • Automate key processes to scale demand generation

More than 70% of B2B companies already use AI in at least one phase of their marketing.

The main ways to use AI in B2B marketing

1. Personalized content generation at scale

With generative AI tools such as ChatGPT or Gemini, you can produce articles, emails, ad copy, and landing pages tailored to each buyer persona much faster and more efficiently. This is especially valuable in technical industries where content must deliver real, practical value—not generic commentary.

2. Workflow and campaign automation

From lead nurturing sequences to multichannel workflows, AI enables campaigns that react to user behavior in real time. This is ideal when integrated with CRMs like HubSpot or Salesforce, where triggers, segmentation, and routing can be automated without losing control of the customer journey.

3. Predictive lead scoring

AI can identify patterns and prioritize leads with stronger buying intent, improving sales team focus and increasing conversion rates. Instead of scoring only on surface engagement, predictive models can incorporate a wider range of signals to better distinguish “interested” from “ready.”

4. Advanced Account-Based Marketing

AI makes ABM more precise by enabling hyper-personalized messaging, identifying target accounts, and adapting content based on industry or buying cycle stage. This increases the effectiveness of complex ABM programs, where relevance and timing are decisive.

5. Behavior analysis and prediction

AI-driven tools can predict which content and channels are likely to perform best, improving strategic planning and media investment. The objective is to move from reactive optimization to proactive decision-making.

How AI solves the biggest B2B marketing challenges

B2B teams face recurring challenges that AI can mitigate effectively:

Lack of brand differentiation

Markets are saturated. AI can support the creation of distinctive, consistent content that improves visibility and strengthens positioning.

Strategies without focus

AI helps structure the funnel, connect marketing and sales activities, and make decisions based on data rather than intuition.

Measurement issues

Many companies don’t trust their reporting. AI can help visualize KPIs in real time and generate actionable insights—not just dashboards.

Limited resources

With AI, smaller teams can operate with “scaled” capacity by automating repetitive work and focusing human effort on strategy and differentiation.

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Best practices for applying AI in B2B marketing

Define your strategy before choosing tools

Don’t start with technology. Start with goals: more leads, higher conversion, better analysis, lower CAC. Then select tools that serve those outcomes.

Align marketing, sales, and technology

AI requires integration. Involve the relevant stakeholders from the beginning to avoid disconnected initiatives and data silos.

Protect data quality

AI is only as effective as the data it learns from. Audit your data sources and ensure consistent taxonomy, governance, and hygiene before you automate.

Use AI as support, not a replacement

Human strategy and creativity remain essential. AI should function as a co-pilot—accelerating execution and insights—while your team stays accountable for positioning and decisions.

Real-world success with AI and automation in B2B

B2B companies that implemented AI-driven strategies together with Sheridan achieved:

  • 42% more leads year over year
  • 13% lower cost per conversion through campaign optimization
  • 60% more keywords ranking in Google Top 10 through AI-assisted content and advanced SEO strategy
  • Conversion rates of 5.69% versus a B2B average of 3.71%

The future of B2B marketing will be predictive and automated

Teams that master data integration, automation, and predictive analytics will be better positioned. AI doesn’t just help you react—it helps you anticipate. In markets with fierce competition and complex buying decisions, AI becomes a catalyst for sustainable growth.

Why Sheridan can help you apply AI strategically

At Sheridan, we combine technology, business, and creativity to scale B2B growth with AI through a proven approach:

  • Omnichannel consulting and execution across SEO, paid media, social, and ABM
  • AI-assisted content production adapted to complex buyer personas
  • Implementation of automated nurturing, scoring, and sales follow-up workflows
  • Demonstrated results across multiple B2B sectors including industry, pharma, tech, and construction

Ready to take your B2B demand generation further with AI

Book a strategy session with our team and discover how we can help.

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About the author

Mateo Rubio

Senior SEO & SEM Analyst

Senior specialist in organic positioning and search engine advertising for B2B environments, with solid experience in the design and execution of SEO/SEM strategies aimed at generating qualified traffic, leads and business opportunities.

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